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. 2018 Feb 19;8:3255. doi: 10.1038/s41598-018-21657-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of the predominant microbiomes under different modes of delivery. (A) Heat map analysis generated with LEfSe showing the taxonomic strains with significantly different abundance in C-section and vaginally delivered neonates. The dendrogram of pathway abundance is colored red to indicate a negative LDA score and green to indicate a positive LDA score. Over/underrepresentation is depicted by a color gradient. (B,C) Correlations were expressed by Spearman’s correlation coefficients. Only the first 30 abundant species were analyzed. Network analysis of C-section-delivered infant meconium microbes (B) and vaginally delivered infant meconium microbes (C). Nodes indicate taxonomic affiliations at the species level. Red lines indicate negative correlations; gray lines indicate positive correlations. The line thickness represents the correlation strength. The size of a node is determined by the thickness of all lines on the node.