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. 2018 Feb 19;8:3255. doi: 10.1038/s41598-018-21657-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Microbial metabolic differences in the meconium microbiome between vaginally delivered and C-section-delivered neonate samples. Genera identified by LEfSe as different between the two biological samples are depicted. Metabolic pathway designations are delineated at the bottom of the figure. The shading intensity and size of the circles indicate the Kendall rank correlation coefficient between matrices. Negative correlations are shown in violet, and positive correlations are shown in blue. Red squares surrounding the circles are indicative of a P value ≤ 0.05.