Table 3. Primary and Secondary Outcomes Stratified by Initial 5ARI Type.
| Outcome | Events/No. at Risk (%) | HR | |||
|---|---|---|---|---|---|
| 5ARI Users, Exposed Cohort | Non-5ARI Users, Unexposed Cohort | Overall HR | Stratified HR (0-1.5 Years) | Stratified HR (>1.5 Years) | |
| Suicide | |||||
| Dutasteride | 16/48 505 (0.03) | 11/48 505 (0.02) | 1.20 (0.52-2.78) | NA | NA |
| Finasteride | 22/44 692 (0.05) | 25/44 692 (0.06) | 0.74 (0.40-1.38) | NA | NA |
| P value for interactiona | NA | NA | .36 | NA | NA |
| Self-harm | |||||
| Dutasteride | 81/48 505 (0.17) | 60/48 505 (0.12) | NA | 1.96 (1.22-3.15) | 0.77 (0.43-2.38) |
| Finasteride | 88/44 692 (0.20) | 70/44 692 (0.16) | NA | 1.80 (1.10-2.94) | 0.89 (0.55-1.44) |
| P value for interactiona | NA | NA | NA | .80 | .72 |
| Depression | |||||
| Dutasteride | 825/46 895 (1.76) | 541/46 895 (1.15) | NA | 2.00 (1.71-2.34) | 1.24 (1.03-1.49) |
| Finasteride | 925/42 949 (2.15) | 688/42 949 (1.60) | NA | 1.87 (1.59-2.19) | 1.20 (1.02-1.41) |
| P value for interactiona | NA | NA | NA | .53 | .80 |
Abbreviations: HR, hazard ratio; NA, not applicable.
a
The interaction P value represents whether there is a significant difference in the outcome based on the type of 5ARI.