Table 1. Baseline Participant Characteristicsa.
| Characteristics | Cephalexin-Metronidazole (n = 202) |
Placebo (n = 201) |
|---|---|---|
| Maternal age, mean (SD), y | 28.5 (5.6) | 28.1 (5.6) |
| Maternal race/ethnicityb | ||
| Non-Hispanic black | 112 (55.4) | 92 (45.8) |
| Non-Hispanic white | 79 (39.1) | 104 (51.7) |
| Hispanic/Latino | 6 (3.0) | 3 (1.5) |
| Other | 5 (2.5) | 2 (1.0) |
| Parity, median (IQR)c | 1 (0-3) | 1 (1-2) |
| Body mass index, mean (SD)d | 40.1 (7.3) | 39.4 (8.4) |
| 30-39.9 | 117 (58.2) | 117 (57.9) |
| 40-49.9 | 65 (32.2) | 66 (32.8) |
| ≥50 | 20 (9.9) | 18 (9.0) |
| Limited prenatal care (<5 prenatal visits) | 16 (8.4) | 16 (8.4) |
| Multifetal gestation | 11 (5.5) | 16 (7.9) |
| Primary cesarean deliverye | 83 (40.9) | 81 (40.3) |
| Medical history | ||
| Tobacco use | 54 (26.7) | 60 (29.8) |
| Pregestational diabetes | 16 (7.9) | 19 (9.4) |
| Chronic hypertension | 49 (24.3) | 51 (25.4) |
| Perinatal and intrapartum factors | ||
| Gestational age at delivery, mean (SD), wk | 37.3 (2.9) | 36.9 (4.0) |
| Gestational diabetes | 41 (20.2) | 29 (14.4) |
| Preeclampsia | 43 (21.3) | 45 (22.4) |
| Group B streptococcus colonized | 65 (32.2) | 68 (33.8) |
| Labor prior to delivery | 70 (34.2) | 76 (37.5) |
| Rupture of membranes | 64 (31.5) | 63 (31.3) |
| Duration of ROM to delivery, median (IQR), h | 11 (5-18) | 6 (4-15) |
| No. of cervical examinations throughout the labor course, median (IQR) | 6 (3-9) | 6 (2-8) |
| Fetal scalp electrode | 38 (18.7) | 36 (17.9) |
| Intrauterine pressure catheter | 39 (19.2) | 42 (20.9) |
| Amnioinfusion | 8 (3.9) | 9 (4.5) |
| Surgical factors | ||
| Scheduled cesarean delivery | 128 (66) | 118 (62) |
| Indication for cesarean delivery | ||
| Repeat | 77 (40) | 79 (42) |
| Labor arrest | 16 (8.3) | 23 (12) |
| Fetal status | 39 (20) | 35 (18) |
| Maternal factor | 16 (8.3) | 26 (14) |
| Breech presentation | 14 (7.3) | 17 (8.9) |
| Suspected macrosomia | 4 (2.1) | 1 (0.5) |
| Multiple gestation | 11 (5.7) | 4 (2.1) |
| Other indication | 16 (8.3) | 5 (2.6) |
| Subcutaneous adipose thickness, mean (SD), cm | 3.4 (1.5) | 3.4 (1.2) |
| Pfannenstiel incision | 191 (94.1) | 190 (94.5) |
| Low transverse hysterotomy | 187 (92.1) | 184 (91.5) |
| Regional anesthesia | 192 (94.6) | 182 (90.5) |
| Estimated blood loss, mean (SD), mL | 920 (258) | 894 (235) |
| Blood transfusion | 17 (8.4) | 11 (5.5) |
| Duration of surgery, mean (SD), min | 71.0 (22.1) | 71.9 (1.7) |
| Suture skin closure | 189 (93.1) | 194 (96.5) |
a
Data are expressed as number (%) of participants unless otherwise specified.
b
Race and ethnic group were self-reported.
c
Interquartile range (IQR) for nonnormally distributed data and mean (SD) for normally distributed data.
d
Body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters using self-reported height and prepregnancy or first-trimester documented weight.
e
Primary cesarean delivery is first-time cesarean delivery in a pregnant woman.