Table 3. Concentrations of Prolactin Across the Study Assay Systems .
| Biotin Use | Prolactin, ng/mL | Day 7 Difference P Value | ||
|---|---|---|---|---|
| Mean of Analyte Concentrations (95% CI) | Mean of Day 7 Difference From the Mean of Baseline and Day 14 (95% CI)a | |||
| cobas | ||||
| Baseline | Without | 11.7 (8.66 to 14.8) | –1.28 (–2.83 to 0.26) | .13 |
| Day 7 | With | 11.3 (8.22 to 14.3) | ||
| Day 14 | Without | 13.4 (10.5 to 16.3) | ||
| Vista | ||||
| Baseline | Without | 9.35 (5.82 to 12.9) | –1.03 (–2.26 to 0.19) | .13 |
| Day 7 | With | 8.93 (5.49 to 12.4) | ||
| Day 14 | Without | 10.6 (7.41 to 13.8) | ||
| Immulite | ||||
| Baseline | Without | 10.7 (3.45 to 18.0) | –0.89 (–2.02 to 0.24) | .15 |
| Day 7 | With | 10.40 (3.55 to 17.3) | ||
| Day 14 | Without | 11.9 (4.83 to 18.9) | ||
| Architect | ||||
| Baseline | Without | 11.4 (4.94 to 18.0) | –1.19 (–2.39 to 0.02) | .08 |
| Day 7 | With | 10.9 (4.94 to 16.8) | ||
| Day 14 | Without | 12.7 (6.68 to 18.8) | ||
Abbreviations: See Figure legends for full names of the assay systems.
SI conversion factors: To convert prolactin from ng/mL to pmol/L, multiply by 43.478.
a
Each analysis was a repeated measures of analysis of variance (ANOVA; mixed linear model), for which the random effect was a participant and the within-participant fixed effect was the study day. The primary comparison was study 7 vs the mean of the baseline and study day 14 measures using a contrast in the ANOVA, ie: study day 7 −(½ baseline + day 14). Data are presented as the absolute mean difference of day 7 from the mean of baseline and day 14 (95% CI). The units for the day 7 difference are the same as those of analyte concentrations.