Table 5. Multivariable Negative Binomial Regression Models Assessing the Association Between Exposure to Combined Antithrombotic Therapy and Hematuria-Related Complications.
| Variable | Association of Antithrombotic Medication Exposure, Stratified by Age at Prescription | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patients 66-69 y | Patients 70-74 y | Patients 75-79 y | Patients 80-84 y | Patients ≥85 y | ||||||
| Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | Unexposed | Exposed | |
| Exposure time (person-years) | 7 688 136 | 4010 | 1 994 048 | 6225 | 1 263 218 | 7500 | 630 170 | 6364 | 354 710 | 4867 |
| Any Hematuria-Related Complication | ||||||||||
| No. of events | 530 442 | 598 | 174 771 | 1182 | 108 154 | 1679 | 50 052 | 1211 | 22 855 | 880 |
| Incidence density ratea | 69.00 | 149.14 | 87.65 | 189.89 | 85.62 | 223.86 | 79.43 | 190.30 | 64.43 | 180.79 |
| Adjusted rate ratio (95% CI)b | 1.39 (1.18-1.62) | 1.96 (1.75-2.19) | 2.36 (2.15-2.60) | 2.06 (1.83-2.32) | 2.03 (1.76-2.34) | |||||
| P value | <.001 | <.001 | <.001 | <.001 | <.001 | |||||
| Emergency Department Visits | ||||||||||
| No. of events | 14 749 | 83 | 5705 | 137 | 4060 | 176 | 2385 | 114 | 1455 | 112 |
| Incidence density ratea | 1.92 | 20.70 | 2.86 | 22.01 | 3.21 | 23.47 | 3.79 | 17.91 | 4.10 | 23.01 |
| Adjusted rate ratio (95% CI)b | 6.03 (4.52-8.05) | 7.35 (5.95-9.09) | 8.08 (6.72-9.72) | 6.94 (5.48-8.79) | 10.48 (8.16-13.45) | |||||
| P value | <.001 | <.001 | <.001 | <.001 | <.001 | |||||
| Hospitalizations | ||||||||||
| No. of events | 37 556 | 88 | 11 368 | 180 | 7324 | 239 | 3794 | 168 | 2052 | 119 |
| Incidence density ratea | 4.89 | 21.95 | 5.70 | 28.92 | 5.80 | 31.87 | 6.02 | 26.40 | 5.79 | 24.45 |
| Adjusted rate ratio (95% CI)b | 2.68 (2.08-3.47) | 3.68 (3.04-4.45) | 4.16 (3.51-4.92) | 3.82 (3.17-4.61) | 3.75 (2.97-4.75) | |||||
| P value | <.001 | <.001 | <.001 | <.001 | <.001 | |||||
| Urologic Procedures | ||||||||||
| No. of events | 478 127 | 427 | 157 694 | 863 | 96 767 | 1264 | 43 870 | 929 | 19 348 | 649 |
| Incidence density ratea | 62.19 | 106.50 | 79.08 | 138.64 | 76.60 | 168.53 | 69.62 | 145.99 | 54.55 | 133.34 |
| Adjusted rate ratio (95% CI)b | 1.09 (0.93-1.27) | 1.56 (1.39-1.76) | 2.00 (1.82-2.22) | 1.75 (1.55-1.99) | 1.65 (1.41-1.93) | |||||
| P value | .30 | <.001 | <.001 | <.001 | <.001 | |||||
a
Incidence density rates are expressed as the number of events per 1000 person-years.
b
Models adjusted for association of participant sex, comorbidity, rurality, income quintile, and geographic region of residence. Rate ratios compare combined antithrombotic exposed and unexposed periods, with stratification by patient age due to a significant interaction between these 2 variables.