Figure 1.

Compounds that bind the androgen receptor.

Notes: (A) Testosterone and DHT are androgens and agonists of the androgen receptor; (B) steroidal antiandrogen, cyproterone acetate, which shares some of the steroid chemical structure of androgens; (C) first-generation nonsteroidal antiandrogens that do not have a steroid chemical structure; (D) second-generation nonsteroidal antiandrogens that share some aspects of the chemical structure of first-generation nonsteroidal antiandrogens with the exception of darolutamide; (E) N-terminal domain antagonist ralaniten.

Note: The green area indicates the common chemical moiety of nonsteroidal antiandrogens that bind in the ligand-binding pocket of the androgen receptor.

Abbreviation: DHT, dihydrotestosterone.