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. 2018 Feb 14;11:781–789. doi: 10.2147/OTT.S144241

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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Downregulation of ISL1 suppresses angiogenesis in breast cancer.

Notes: (A) MCF-7 cells were treated with vector, ISL1 or SCR, ISL1 siRNA (siISL1), respectively. After transfection for 48 h, the HUVECs were incubated with conditional media (CM) from MCF-7 cells. The number of tubes formed indicates the effect of ISL1 on angiogenesis. Magnification: 40×, scale bars =250 μm. (B) The graph indicates the relative number of tubes. *p<0.05, ISL1 vs vector, siISL1 vs SCR.

Abbreviations: HUVECs, human umbilical vein endothelial cells; SCR, scramble siRNA.