Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mode of action of CDK4/6 inhibitors.
Notes: Palbociclib, ribociclib and abemaciclib inhibit the complex CDK4/cyclin D1, responsible for the phosphorylation and inhibition of the Rb tumor-suppressor gene’s product. When Rb is phosphorylated, the cell proceeds from G1 to Phase S of the cell cycle, replicating DNA and preparing for mitosis.
Abbreviation: Rb, retinoblastoma.
