Table 1.

CDK4/6 inhibitors’ selectivity

	Palbociclib	Ribociclib	Abemaciclib
IC50 for CDK/cyclin complexes (nmol/L)
CDK4/cyclin D1	11	10	2
CDK6/cyclin D1	16	39	10
CDK1/cyclin B	>10,000	>10,000	1,627±666
CDK2/cyclin A/E	>70,000	>10,000	504±298
CDK5/p25	>40,000	>10,000	355
CDK9/cyclin T1	NR	NR	57±42

Notes: Data are presented as average of independent determinations ± SD. Data from Gelbert et al23 and Tripathy et al.25 For number of repeats and other information, please see cited references.

Abbreviation: NR, not reported.