Table 3.
Study of B and BNP treatment on the liver parameters in NDEA-exposed carcinogenesis in rats
| Sr no | Groups | Initial day body weight (g) | Final day body weight (g) | Weight variation (g) | Liver weight (g) | Tumor incidence no |
|---|---|---|---|---|---|---|
| 1 | NC | 120.00±3.34 | 146.00±4.27 | 26.00±2.12 | 8.26±0.93 | 0.00±0.00 |
| 2 | CC | 121.00±2.23 | 102.00±1.46 | −19.00±2.16 | 13.97±1.62 | 32.00±1.31 |
| 3 | PC | 115.00±4.68 | 125.00±3.15*** | 10.00±1.26*** | 10.43±1.71*** | 6.00±0.83*** |
| 4 | B (50 mg/kg) | 121.00±1.89 | 132.00±4.25*** | 11.00±1.82*** | 12.78±0.73 | 19.00±0.97*** |
| 5 | B (100 mg/kg) | 118.00±2.15 | 130.00±2.12*** | 12.00±2.93*** | 12.03±1.25* | 14.00±1.01*** |
| 6 | BNP (50 mg/kg) | 114.00±2.12 | 130.00±2.19*** | 16.00±3.75*** | 11.61±0.63** | 12.00±0.84*** |
| 7 | BNP (100 mg/kg) | 120.00±1.89 | 142.00±4.78*** | 22.00±1.98*** | 9.36±0.39*** | 4.00±0.31*** |
Notes: Data are represented as mean ± SD (n=8). Statistically significant differences were observed between CC and test groups (one-way ANOVA followed by Bonferroni multiple comparison test;
*
p<0.05,
**
p<0.01 and
***
p<0.001).
Abbreviations: B, betulinic acid; BNP, B nanoparticles; NDEA, N-nitrosodiethylamine; NC, normal control; CC, carcinogen control; PC, positive control; SD, standard deviation; ANOVA, analysis of variance; Sr no, serial number.