Table 6.
Difference between calculated AUC of the ROC curve after rescoring with DrugScore and original AUC of the ROC curve for each target (∗statistically significant changes).
| Receptor | d − v |
|---|---|
| THB∗ | −0.2876 |
| MK01∗ | −0.1738 |
| COMT∗ | −0.1625 |
| TYSY∗ | −0.1491 |
| WEE1∗ | −0.1083 |
| MK10∗ | −0.0929 |
| AKT2∗ | −0.0787 |
| ROCK1 | −0.0715 |
| NOS1 | −0.0641 |
| CP2C9 | −0.0605 |
| PYRD | −0.0582 |
| CXCR4 | −0.0569 |
| KIF11 | −0.0518 |
| GRIK1 | −0.0467 |
| FA7 | −0.0403 |
| FKB1A | −0.036 |
| PYGM | −0.0327 |
| ADA | −0.02 |
| KITH | 0.0107 |
| INHA | 0.0262 |
| SAHH | 0.0303 |
| PUR2 | 0.0364 |
| PLK1 | 0.0492 |
| GLCM | 0.062 |
| HX4 | 0.0753 |
| NRAM | 0.0812 |
| PA2GA∗ | 0.0854 |
| DEF∗ | 0.0906 |
| MCR∗ | 0.1411 |
| HS90A∗ | 0.1439 |
| XIAP∗ | 0.1577 |
| RENI∗ | 0.1605 |