Table 5.
Association of HLA-B alleles with carbamazepine-induced DRESS.
| HLA-B alleles | Carbamazepine-induced DRESS (n = 5) | Controls (n = 271) | Thai population (n = 470) | Carbamazepine-induced DRESS cases versus tolerant controls | Carbamazepine-induced DRESS cases versus Thai population | ||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | ||||
| B∗15:02 | 1 (20.00%) | 11 (4.06%) | 71 (15.11%) | 5.91 (0.61–57.36) | 0.126 | 1.41 (0.16–12.75) | 0.562 |
| B∗18:01 | 1 (20.00%) | 29 (10.70%) | 36 (7.66%) | 2.09 (0.23–19.30) | 0.440 | 3.01 (0.33–27.68) | 0.325 |
| B∗27:04 | 1 (20.00%) | 12 (4.43%) | 19 (4.04%) | 5.40 (0.56–52.04) | 0.216 | 5.93 (0.63–55.68) | 0.194 |
| B∗27:06 | 1 (20.00%) | 8 (2.95%) | 12 (2.55%) | 8.22 (0.82–82.09) | 0.154 | 9.54 (0.99–91.90) | 0.130 |
| B∗40:01 | 2 (40.00%) | 41 (15.13%) | 58 (12.34%) | 3.74 (0.61–23.08) | 0.174 | 4.74 (0.78–28.94) | 0.122 |
| B∗51:01 | 1 (20.00%) | 21 (7.75%) | 40 (8.51%) | 2.98 (0.32–27.85) | 0.339 | 2.69 (0.29–24.63) | 0.382 |
| B∗58:01 | 2 (40.00%) | 22 (8.12%) | 57 (12.13%) | 7.55 (1.20–47.58) | 0.032∗ | 4.83 (0.79–29.53) | 0.088 |
DRESS: drug reaction with eosinophilia and systemic symptoms; OR: odds ratio; 95% CI: confidence interval 95%. ∗P value less than 0.05.