Table 1.
Preparation of Air-Stable, Storable Palladium Reagents of Interest in Chemical Biologya and Subsequent S-Arylation of an Unprotected Peptideb
| ||||
|---|---|---|---|---|
|
| ||||
| name | Ar | X | isolated yield of OA (%) | S-arylation (%) |
| OA-20 |
|
OTf | 94 | 99 |
| OA-21 |
|
Br | 99 | 99 |
| OA-22 |
|
Cl | 86 | 99 |
| OA-23 |
|
Br | 82 | 99 |
| OA-24 |
|
Cl | 94 | 99 |
| OA-25 |
|
Br | 99 | 99 |
a
Reported isolated yields are an average of two runs after purification.
b
S-Arylation conversions determined by LC-MS analysis of the crude mixture; see SI for details.