. Author manuscript; available in PMC: 2018 May 1.

Published in final edited form as: J Clin Psychiatry. 2017 Nov-Dec;78(9):1337–1343. doi: 10.4088/JCP.15m10314

Table 2.

Genetic Risk Score Analysis of Patients With Early-onset Bipolar Disorder Compared With Controls

Groups Compared	Risk Score	Mean Risk Score		OR	P Value
Groups Compared	Risk Score	Cases	Controls	OR	P Value
Adult cases vs controls	SC-GRS	4.10	4.06	1.01	.71
Adult cases vs controls	OR-GRS	0.27	0.26	1.10	.56
TEAM vs controls	SC-GRS	4.48	4.06	1.10	.11
TEAM vs controls	OR-GRS	0.30	0.26	1.58	.24
Adult EOC vs controls	SC-GRS	4.38	4.06	1.08	.06
Adult EOC vs controls	OR-GRS	0.32	0.26	1.77	.02
TEAM+adult EOC vs controls	SC-GRS	4.41	4.06	1.08	.02
TEAM+adult EOC vs controls	OR-GRS	0.31	0.26	1.74	.01
TEAM+adult EOC vs adult LOC	SC-GRS	4.41	4.05	1.09	.047
TEAM+adult EOC vs adult LOC	OR-GRS	0.31	0.26	1.74	.06
Adult LOC vs controls	SC-GRS	4.05	4.06	0.99	.96
Adult LOC vs controls	OR-GRS	0.26	0.26	1.05	.85

Abbreviations: EOC, early-onset cases; LOC, late-onset cases; OR, odds ratio; OR-GRS, odds ratio–weighted genetic risk score; SC-GRS, simple count genetic risk score; TEAM, Treatment of Early Age Mania.