Table 5.
Association of Candidate Single-Nucleotide Polymorphisms With Early-onset Bipolar Disorder
| TEAM Cases vs Controls
|
Adult EOC vs Controls s
|
TEAM+Adult EOC vs Controls s
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Gene | Control MAF | MAF TEAM | OR | P Value | MAF Mayo EOC | OR | P Value | OR | P Value |
| rs10848632 | CACNA1C | 0.39 | 0.49 | 1.54 | .017 | 0.42 | 1.12 | .32 | 1.22 | .056 |
| rs1006737 | CACNA1C | 0.35 | 0.39 | 1.20 | .34 | 0.36 | 1.08 | .52 | 1.11 | .33 |
| rs1024582 | CACNA1C | 0.35 | 0.40 | 1.23 | .26 | 0.38 | 1.12 | .34 | 1.15 | .19 |
| rs4765913 | CACNA1C | 0.23 | 0.27 | 1.28 | .24 | 0.24 | 1.08 | .59 | 1.13 | .32 |
| rs1938526 | ANK3 | 0.07 | 0.07 | 1.02 | .95 | 0.10 | 1.37 | .10 | 1.28 | .16 |
| rs9804190 | ANK3 | 0.23 | 0.24 | 1.07 | .76 | 0.20 | 0.85 | .26 | 0.91 | .43 |
| rs10994336 | ANK3 | 0.06 | 0.07 | 1.06 | .88 | 0.09 | 1.49 | .049 | 1.37 | .086 |
| rs12576775 | ODZ4 | 0.16 | 0.20 | 1.25 | .34 | 0.18 | 1.14 | .38 | 1.17 | .24 |
Abbreviations: EOC, early-onset cases; MAF, minor allele frequency; OR, odds ratio; SNP, single-nucleotide polymorphism; TEAM, Treatment of Early Age Mania.