Table 2.
Effects of sirolimus on rates of change in pulmonary function and arterial blood gas
| Variable | Change per month (Paired) | ||
|---|---|---|---|
| Before sirolimus | After sirolimus | P value | |
| Pulmonary Function | (N = 18) | ||
| FEV1 (mL) | −31.12 ± 30.78 | 16.11 ± 36.00 | 0.002 |
| FEV1/pred (%) | −0.95 ± 0.82 | 0.30 ± 0.89 | < 0.001 |
| FVC/pred (%) | −1.13 ± 0.93 | 0.71 ± 1.36 | 0.001 |
| FEV1/FVC (%) | −0.82 ± 1.36 | 0.78 ± 2.16 | 0.019 |
| RV/pred (%) | 2.50 ± 9.01 | 0.16 ± 8.30 | 0.497 |
| TLC/pred (%) | 1.02 ± 4.49 | 1.15 ± 6.20 | 0.953 |
| RV/TLC (%) | 0.78 ± 2.38 | 0.41 ± 2.58 | 0.688 |
| DLCO/pred (%) | −0.72 ± 1.34 | 1.10 ± 2.28 | 0.043 |
| Arterial Blood Gas | (N = 17) | ||
| PaO2 (mmHg) | −0.55 ± 0.60 | 0.30 ± 1.19 | 0.018 |
| PaCO2 (mmHg) | 0.005 ± 0.327 | 0.058 ± 0.194 | 0.170 |
| P(A-a)O2 (mmHg) | 0.31 ± 0.92 | −0.75 ± 1.28 | 0.037 |
Abbreviations: FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, RV residual volume, TLC total lung capacity, DLCO diffusing capacity for carbon monoxide, PaO2 partial pressure of oxygen in arterial blood, PaCO2 partial pressure of carbon dioxide in arterial blood, P(A-a)O2 alveolar-arterial oxygen gradient
Data are presented as mean ± SD