Table 4.
Adverse events in patients with sirolimusa
| Adverse events | Number of patients | Percentage (%) |
|---|---|---|
| Mouth ulcers | 43 | 43.9 |
| Menstrual abnormality | 26 | 26.5 |
| Hyperlipidemia | 15 | 15.3 |
| Acneiform rash | 15 | 15.3 |
| Diarrhea | 2 | 2.0 |
| Fever | 2 | 2.0 |
| Peripheral edema | 2 | 2.0 |
| Gingival hyperplasia | 2 | 2.0 |
| Infections | 1 | 1.0 |
| Hypertension | 1 | 1.0 |
| Non-productive cough | 1 | 1.0 |
| Nasal allergy | 1 | 1.0 |
| Low back pain | 1 | 1.0 |
| Chest pain | 1 | 1.0 |
| Alopecia | 1 | 1.0 |
| Toothache | 1 | 1.0 |
| Arthralgia (finger) | 1 | 1.0 |
| Dizziness | 1 | 1.0 |
| Palpitation | 1 | 1.0 |
| Elevated alanine aminotransferase | 1 | 1.0 |
aThree patients stopped sirolimus because of severe adverse effects, which were elevated liver alanine aminotransferase, lung infection and fever. All of them initiated the therapy again after 2 to 6 months and were free of severe adverse events