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. 2018 Feb 20;6:13. doi: 10.1186/s40478-018-0516-2

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Histology and immunohistochemical staining of PrP in two brain regions of a tg66 mouse injected with Q227X brain homogenate at 743 dpi, and an uninfected aged control tg66 mouse (age 649 days). Panels a, c, e, g show PrP staining with biotinylated-3F4 antibody, and panels b, d, f, h show H&E staining. Uninfected cortex (a, b), Q227X injected cortex (c, d), uninfected pons (e, f), Q227X-injected pons (g, h). Panels a and c show darker tan staining than panels e and g due to a higher level of background PrPC in cortex compared to pons. No prion disease vacuoles or significant deposits suggestive of PrPSc were observed in uninfected or the Q227X-injected mice. Scale bar in panel a is 50 μm and is valid for all panels