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. 2018 Feb 19;19:23. doi: 10.1186/s13059-018-1392-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Maximum likelihood phylogeny of NLRs in grasses identifies evolutionary hotspots of NLRs with integrated domains. a The maximum likelihood tree of the NB-ARC family in grasses (4184 proteins, nine species) showing occurrence of integrated domain (ID) across the phylogeny (red branches). b Close-up of MIC1 (red) as well as its outgroup clades C15 (blue), C14 (brown), and ancestral clade C13 (cyan) showing the key bootstrap support values. c Wordcloud summary of the integrated domain diversity from MIC1. E-value cut-off for presence of an ID domain, 0.001