Table 3.

Cox proportional hazards models used to evaluate influence of baseline characteristics and medical history on survival

	Model 1 unadjusted		Model 2 adjusted for age and sex		Model 3: model 2 plus MMSE and duration of complaints
	HR (95% CI)	p value	HR (95% CI)	p Value	HR (95% CI)	p Value
Demographics
Male sexa	1.57 (1.20–2.07)	0.001	1.60 (1.22–2.11)	0.001	1.79 (1.35–2.37)	0.000
Age	1.27 (1.11–1.46)	0.001	1.29 (1.12–1.48)	0.000	1.33 (1.15–1.53)	0.000
Years of education	0.99 (0.86–1.13)	0.844	0.97 (0.84–1.11)	0.636	1.0 (0.90–11.9)	0.671
Years of complaints	0.88 (0.76–1.03)	0.107	0.88 (0.76–1.03)	0.103	0.87 (0.74–1.01)	0.060
APOE ε4 carriera	0.79 (0.59–1.06)	0.114	0.81 (0.61–1.09)	0.163	0.81 (0.60–1.09)	0.170
Activities of daily living (DAD)b	1.13 (0.97–1.31)	0.124	1.11 (0.95–1.29)	0.204	1.09 (0.94–1.26)	0.278
Medical history
Smoking presenta	1.18 (0.89–1.55)	0.250	1.09 (0.82–1.45)	0.541	1.12 (0.85–1.49)	0.419
Hypertension presenta	1.24 (0.94–1.64)	0.130	1.11 (0.83–1.49)	0.467	1.10 (0.82–1.47)	0.528
Hypercholesterolemia presenta	0.86 (0.62–1.19)	0.861	0.73 (0.52–1.01)	0.059	0.75 (0.54–1.05)	0.091
Diabetes mellitus presenta	0.72 (0.43–1.22)	0.228	0.62 (0.37–1.06)	0.079	0.65 (0.40–1.05)	0.108
Cardiovascular disease presenta	1.35 (0.99–1.84)	0.060	1.07 (0.77–1.48)	0.700	1.09 (0.78–1.51)	0.625
No. of medications	1.17 (1.03–1.33)	0.017	1.08 (0.95–1.24)	0.251	1.11 (0.97–1.28)	0.125

Abbreviations: APOE Apolipoprotein E, DAD Disability Assessment for Dementia, MMSE Mini Mental State Examination

Data are presented as HR (95% CI) using pooled data of 15 imputations per SD increase for continuous variables or for the presence of the dichotomous variable for mortality

^a Dichotomous variable

^b Because a lower score indicates worse performance, these scores were inverted