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. 2018 Feb 20;15:50. doi: 10.1186/s12974-018-1061-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — E-30 strain-specific effects on barrier integrity of HIBCPP cells Barrier integrity of HIBCPP cells was evaluated via measurement of the transepithelial electrical resistance (TEER) (a) and the paracellular permeability for the low molecular weight molecule dextran-TexasRed (3000 kDa) (b) at indicated time points after infection with E-30 Bastianni, 13-311, 13-759, or 14-397 and compared to uninfected controls (a) TEER values at the start of the experiment (white bars), after 5 h (light gray), after 24 h (medium gray) and after 28 h (dark gray) are shown. Data are shown as mean + SD of 11 independent experiments carried out in triplicates. p values compare the TEER at 5, 24, and 28 h after infection for each viral strain with the respective control at 0 h (**p < 0.01, ****p < 0.0001). b Evaluation of the paracellular permeability was carried out after 24 h of infection of HIBCPP cell layers with different viral strains via the addition of dextran to the upper compartment of the filter for 4 h. Data shown are mean + SD of five independent experiments each performed in triplicates. p values were calculated when comparing paracellular permeability of all infected and uninfected conditions to E-30 Bastianni infected HIBCPP cells (***p < 0.001)