Table 3.
Genotype and allele distributions of MMP1, 3, and 12 polymorphisms
| Gene (polymorphism) | RHD n (%) |
Controls n (%) |
p value | OR (95% CI) |
|---|---|---|---|---|
| MMP1 (rs1799750) | ||||
| Genotype | 0.072* | |||
| 1G/1G | 6 (6.7) | 15 (16.7) | – | (Ref.) |
| 1G/2G | 43 (47.8) | 44 (48.9) | 0.09 | 2.455 (0.87–6.926) |
| 2G/2G | 41 (45.6) | 31 (34.4) | 0.03 | 3.227 (1.118–9.31) |
| Allele | ||||
| 1G | 55 (30.6) | 74 (41.1) | – | (Ref.) |
| 2G | 125 (69.4) | 106 (58.9) | 0.048 | 0.644 (0.416–0.996) |
| MMP3 (rs3025058) | ||||
| Genotype | 0.509* | |||
| 6A/6A | 65 (72.2) | 67 (74.4) | – | (Ref.) |
| 5A/6A | 21 (23.3) | 22 (24.4) | 0.983 | 0.993 (0.498–1.981) |
| 5A/5A | 4 (4.4) | 1 (1.1) | 0.230 | 3.908 (0.421–36.242) |
| Allele | ||||
| 6A | 151 (83.9) | 156 (86.7) | – | (Ref.) |
| 5A | 29 (16.1) | 24 (13.3) | 0.473 | 1.24 (0.689–2.231) |
| MMP12 (rs2276109) | ||||
| Genotype | 0.767* | |||
| A/A | 85 (94.4) | 83 (92.2) | – | (Ref.) |
| A/G | 5 (5.6) | 7 (7.8) | 0.569 | 0.708 (0.215–2.324) |
| G/G | 0 (0.0) | 0 (0.0) | – | – |
| Allele | ||||
| A | 175 (97.2) | 173 (96.1) | – | (Ref.) |
| G | 5 (2.8) | 7 (3.9) | 0.576 | 0.717 (0.223–2.307) |
The genotype and allele with p < 0.05 are shown in bold fonts
OR odds ratio, CI confidence interval, and Ref. reference
*p value calculated from 2 × 3 contingency table