Table 3.
FTO genotype and measures of body weight stratified by ethnicity and protein intake
| Low protein (≤ median intake)a | High protein (> median intake)a | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| rs1558902 genotype | rs1558902 genotype | Interaction | |||||||
| TT | TA | AA | p b | TT | TA | AA | p b | p c | |
| Caucasian | |||||||||
| Subjects (n) | 115 | 197 | 68 | 141 | 170 | 68 | |||
| Body mass index (kg/m2) | 22.4 ± 0.3d | 23.1 ± 0.2 | 23.1 ± 0.4 | 0.2 | 23.3 ± 0.3 | 24.1 ± 0.3 | 23.7 ± 0.4 | 0.17 | 0.95 |
| Waist circumference (cm) | 73.6 ± 0.7 | 76.2 ± 0.6 | 75.4 ± 1.1 | 0.07 | 75.5 ± 0.7 | 76.6 ± 0.8 | 75.9 ± 1.0 | 0.17 | 0.99 |
| East Asian | |||||||||
| Subjects (n) | 215 | 55 | 9 | 207 | 70 | 2 | |||
| Body mass index (kg/m2) | 21.5 ± 0.2c | 22.5 ± 0.3b | 25.0 ± 1.3a | < 0.0001 | 21.8 ± 0.2 | 21.5 ± 0.3 | 22.4 ± 1.9 | 0.58 | 0.01 |
| Waist circumference (cm) | 70.6 ± 0.5b | 72.0 ± 0.9b | 78.9 ± 3.4a | 0.0006 | 71.4 ± 0.5 | 71.0 ± 0.8 | 68.1 ± 1.3 | 0.34 | 0.007 |
| South Asian | |||||||||
| Subjects (n) | 42 | 40 | 5 | 42 | 37 | 8 | |||
| Body mass index (kg/m2) | 23.8 ± 0.7 | 23.4 ± 0.7 | 24.4 ± 2.3 | 0.83 | 23.5 ± 0.5 | 23.9 ± 0.8 | 25.0 ± 2.7 | 0.86 | 0.86 |
| Waist circumference (cm) | 76.8 ± 1.7 | 74.4 ± 1.8 | 76.3 ± 5.2 | 0.75 | 76.0 ± 1.3 | 75.9 ± 2.5 | 77.8 ± 5.4 | 0.98 | 0.76 |
Groups without a common letter differ after a Tukey-Kramer post hoc test (p<0.05)
aLow and high protein intakes determined using ethnicity-specific medians: Caucasians (17% energy intake), East Asians (18% energy intake), South Asians (17% energy intake)
bDetermined using GLMs adjusted for age and sex
cInteractions between rs1558902 genotype and energy-adjusted protein intake on markers of body mass determined using GLMs adjusted for age and sex
dMean ± SE (all such values)