Table 2.
Spearman’s correlation analysis between CT parameters, pulmonary function tests, functional markers, blood and sputum markers
| %LAA<− 950 | E/I MLD | Pi10 | |
|---|---|---|---|
| Pulmonary Function Tests | |||
| FEV1% | −0.49*** | −0.63*** | − 0.11 |
| FVC% | 0.06 | −0.21* | − 0.31** |
| FEV1/FVC | −0.72*** | − 0.64*** | 0.12 |
| TLCO% | −0.51*** | −0.34*** | 0.01 |
| RV% | 0.36*** | 0.64*** | −0.05 |
| RV/TLC | 0.19* | 0.62*** | 0.16 |
| Functional Markers | |||
| 6MWD (meters) | −0.14 | −0.10 | − 0.11 |
| Desaturation on exertion (%) | 0.56*** | 0.27** | −0.11 |
| Blood Markers | |||
| Blood neutrophils (109L) | −0.06 | −0.11 | 0.15 |
| Blood eosinophils (109L) | 0.15 | 0.01 | 0.01 |
| Fibrinogen (g/L) | −0.20* | − 0.04 | 0.21* |
| CRP (mg/L) | −0.27** | −0.28** | 0.25* |
| Procalcitonin (μg/L) | −0.01 | −0.06 | 0.18* |
| Sputum Differential | |||
| %neutrophils | 0.17 | 0.19 | −0.10 |
| %eosinophils | 0.16 | 0.04 | −0.11 |
Spearman’s r values given. N = 122 apart from associations with gas transfer (n = 117), plethysmography (n = 113), 6MWT parameters (n = 120), blood white cells and procalcitonin (n = 121), fibrinogen (n = 109) and sputum white cell differential (n = 66). *p < 0.05, **p < 0.01, ***p < 0.001