Table 3.
Multiple regression analysis predicting FEV1%, TLCO%, RV/TLC, 6MWD, desaturation on exertion, CRP, fibrinogen and sputum neutrophils
| B coefficient | Standardised B coefficient | significance | |
|---|---|---|---|
| FEV1% | |||
| %LAA<− 950 | − 0.42 | − 0.34 | < 0.001 |
| E/I MLD | − 180.8 | − 0.56 | < 0.001 |
| BMI | −0.56 | − 0.20 | 0.010 |
| TLCO% | |||
| %LAA<− 950 | −0.62 | −0.37 | < 0.001 |
| FEV1% | 0.49 | −0.39 | < 0.001 |
| Gender | −7.5 | −0.19 | 0.014 |
| RV/TLC | |||
| E/I MLD | 0.75 | 0.30 | 0.003 |
| FEV1% | −0.003 | −0.32 | 0.002 |
| Gender | 0.07 | 0.28 | < 0.001 |
| 6MWD (metres) | |||
| FEV1% | 3.03 | 0.41 | < 0.001 |
| BMI | −5.19 | −0.26 | 0.003 |
| Gender | −38.2 | −0.17 | 0.044 |
| Desaturation on exertion (%) | |||
| %LAA<−950 | 0.041 | 0.73 | < 0.001 |
| BMI | 0.032 | 0.248 | 0.004 |
| Gender | 0.233 | 0.164 | 0.037 |
| CRP (mg/L) | |||
| %LAA<− 950 | −0.026 | −0.34 | < 0.001 |
| Fibrinogen (g/L) | |||
| %LAA<−950 | −0.020 | −0.28 | 0.003 |
| Age | 0.022 | 0.216 | 0.020 |
| Sputum Neutrophils (%) | |||
| Current smoker | −21.1 | −0.29 | 0.018 |
%LAA<−950, E/I MLD, PI10, bronchiectasis, FEV1% and demographics variables (age, gender, current smoking status, pack years and BMI) were combined into a regression model to predict each of the dependent variables. Only variables that made a significant difference to the model are included in the results. The natural log of CRP and desaturation on exertion (+ 1) were used for this analysis to normalise the distribution of the residuals