Table 2.

Gene regulation in AEII cells in response to CeO₂ and BaSO₄ after different exposure periods

Array	Gene		CeO2			BaSO4
			1 day	28 days	90 days	1 day	28 days	90 days
Inflammatory cytokines and receptors	Ccl3	C–C motif chemokine ligand 3
	Ccl17	C–C motif chemokine ligand 17
	Cx3cr1	C–X3–C motif chemokine receptor 1
	Il1α	Interleukin 1 alpha
	Il1β	Interleukin 1 beta
	Il1rn	Interleukin 1 receptor antagonist
	Tnfsf4	Tumor necrosis factor superfamily member 4
	Ccl2	C–C motif chemokine ligand 2
	Ccl4	C–C motif chemokine ligand 4
	Ccl7	C–C motif chemokine ligand 7
	Ccl11	C–C motif chemokine ligand 11
	Ccl20	C–C motif chemokine ligand 20
	Ccl22	C–C motif chemokine ligand 22
	Ccl24	C–C motif chemokine ligand 24
	Pf4	platelet factor 4
	Cxcl9	C–X–C motif chemokine ligand 9
	Cd40lg	CD40 ligand
	Il2rb	Interleukin 2 receptor, beta
Oxidative stress	Lpo	Lactoperoxidase
	Noxo1	NADPH oxidase organizer 1
	Hba1	Hemoglobin alpha, adult chain 2
	Scd1	Stearoyl-Coenzyme A desaturase 1
	Krt1	Keratin 1
DNA repair	Msh5	mutS homolog 5
	Exo1	Exonuclease 1
	Mutyh	MutY homolog (E. coli)
Apoptosis	Birc5	Baculoviral IAP repeat-containing 5
Lung cancer	Cyp1b1	Cytochrome P450, family 1, subfamily b, polypeptide 1
	Fabp4	Fatty acid binding protein 4
	Mmp12	Matrix metallopeptidase 12
	Opcml	Opioid binding protein/cell adhesion molecule-like
	Tcf21	Transcription factor 21
	Thbs2	Thrombospondin 2
	Top2a	Topoisomerase (DNA) II alpha
Total	34		11	18	24	9	10	15

upregulation; downregulation; up- or downregulation (differences between CeO₂ dose groups); cut-off: FR ≤ − 2.0 or ≥ 2.0