Table 3.
Gene regulation in liver and kidney in response to 90 days CeO2 and BaSO4 exposure
| Array | Gene | CeO2 | BaSO4 | |||
|---|---|---|---|---|---|---|
| Liver | Kidney | Liver | Kidney | |||
| Inflammatory cytokines and receptors | Ccr2 | Chemokine (C–C motif) receptor 2 |
|
|
||
| Cx3cl1 | Chemokine (C–X3–C motif) ligand 1 |
|
||||
| Cxcl12 | Chemokine (C–X–C motif) ligand 12 |
|
||||
| Cxcr2 | Chemokine (C–X–C motif) receptor 2 |
|
||||
| Cxcr3 | Chemokine (C–X–C motif) receptor 3 |
|
|
|||
| Il2rg | Interleukin 2 receptor, gamma |
|
||||
| Osm | Oncostatin M |
|
|
|||
| Ccl2 | Chemokine (C–C motif) ligand 2 |
|
||||
| Ccl9 | Chemokine (C–C motif) ligand 9 |
|
|
|||
| Cxcr5 | Chemokine (C–X–C motif) receptor 5 |
|
||||
| Spp1 | Secreted phosphoprotein 1 |
|
||||
| Oxidative stress | Gpx2 | Glutathione peroxidase 2 |
|
|
||
| Lpo | Lactoperoxidase |
|
|
|||
| Ncf2 | Neutrophil cytosolic factor 2 |
|
|
|||
| Scd1 | Stearoyl-Coenzyme A desaturase 1 |
|
|
|
|
|
| Alb | Albumin |
|
|
|||
| Epx | Eosinophil peroxidase |
|
||||
| Gclc | Glutamate-cysteine ligase, catalytic SU |
|
||||
| Gclm | Glutamate cysteine ligase, modifier SU |
|
||||
| Hba1 | Hemoglobin alpha, adult chain 2 |
|
||||
| Mpo | Myeloperoxidase |
|
||||
| Ngb | Neuroglobin |
|
|
|||
| Txnip | Thioredoxin interacting protein |
|
|
|||
| DNA repair | Lig4 | Ligase IV, DNA, ATP-dependent |
|
|
|
|
| Smug1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1 |
|
||||
| Xrcc2 | X-ray repair complementing defective repair in Chinese hamster cells 2 |
|
||||
| Brca1 | Breast cancer 1 |
|
||||
| Total | 27 | 13 | 17 | 6 | 6 | |
upregulation;
downregulation;
up- or downregulation (differences between dose groups); cut-off: FR ≤ − 2.0 or ≥ 2.0