Table 2.
Sr. No. | Group | Passive cutaneous anaphylaxis | Active anaphylaxis | Mast cell degranulation | |||
---|---|---|---|---|---|---|---|
Blueing reaction mm3 | Behavioural symptoms (% of mortality) | Respiratory score | Intact | Degranulated | |||
1 | Control | 00 | Normal | 00 (00) | 100 | 00 | |
2 | Negative control | 78.39±3.15 | Respiratory distress/collapse 3–5 min (70%) | 8.80±5.2 (65%) | 22.62±2.94## | 79.32±4.72## | |
3 | Corilagin 10 mg/kg | 69.17±3.09 | Dysponea 5–8 min (40%) | 6.25±3.15 (40%) | 31.72±2.45* | 67.37±4.31** | |
4 | Corilagin 20 mg/kg | 54.92±2.90 | Dysponea 15–20 min (25%) | 4.10±1.28 (25%) | 43.89±3.56** | 56.18±3.78** | |
5 | Corilagin 40 mg/kg | 47.36±1.97 | Normal | 2.74±1.45 (15%) | 55.73±4.71** | 44.27±3.26** | |
6 | STD | Dexomethasone | 43.18±2.69 | Normal | 2.36±0.75 (15%) | – | – |
Ketotifen | – | – | – | 62.39±4.26** | 38.29±2.46** |
Means ±SD (n=6),
p<0.01 than control,
p<0.05,
p<0.01 than negative control.