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. Author manuscript; available in PMC: 2018 Dec 18.
Published in final edited form as: Analyst. 2017 Dec 18;143(1):21–32. doi: 10.1039/c7an01046j

Figure 6.

Figure 6

Schematic of dual positive-negative selection chip. Beads in the first pinch are coated with multiple non-target proteins for negative selection, while beads in the second pinch are coated with the target of interest. The oligos are flowed through inlet 1, and only sequences with affinity for the target but not for any of the negative proteins will bind in the second pinch. These oligos are then eluted by the addition of DDT to inlet 2. Adapted from Wang et al80 with permission from the American Chemical Society.