Fig. 3.
SNX-1/SNX-6 and SNX-3 redundantly inhibit EV release. (A) EV release was not increased in a 26-cell snx-3 mutant embryo expressing the mCherry::PHPLC1∂1::ZF1 plasma membrane reporter. (B) EVs labeled with mCherry::PHPLC1∂1::ZF1 (arrow) accumulate between cell contacts in a 26-cell snx-3 mutant treated with snx-6 RNAi. (C and D) GFP::TAT-5 is mislocalized to cytoplasmic compartments in snx-1 mutants treated with snx-3 RNAi, as well as in snx-3 mutants treated with snx-6 RNAi. [Scale bars: A, 10 μm (also applies to B); C, 10 μm (also applies to D).]