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. 2018 Feb 13;9:67. doi: 10.3389/fmicb.2018.00067

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Copyright © 2018 Gupta, Lo and Son.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Partial sequence alignment of a conserved region of (A) ATP-dependent helicase showing a four amino acid insertion that is specific for the “Terrae” + “Triviale” clades and (B) UDP-N-acetylmuramate—L-alanine ligase showing a four amino acid insertion that is specific for only the members of the “Terrae” clade but lacking in members of the “Triviale” clade as well as other mycobacteria. More detailed alignments of these CSIs are shown in Supplementary Figures 54 and 74, respectively. Additional CSIs that are specific for this clade are shown in Supplementary Figures 35, 54–84 and summarized in Table 6.