Table 6.

Conserved Signature Indels (CSIs) specific for members of the “Terrae” + “Triviale” clades or only the “Terrae” clade.

Protein name	Accession number	Figure number	Indel size	Indel position	Specificity
ATP-dependent helicase	WP_083036071	Figure 9A Supplementary Figure 54	4aa ins	1,144–1,184	“Terrae” + “Triviale” Clades
PDZ domain-containing protein	WP_083035840	Supplementary Figure 55	1aa del	290–324
Ferredoxin reductase	WP_083035874	Supplementary Figure 56	3aa ins	199–263
DUF2236 domain-containing protein	WP_083036515	Supplementary Figure 57	4aa del	37–80
Hypothetical protein	WP_083040170	Supplementary Figure 58	1aa ins	100–141
DUF4185 domain-containing protein	WP_083070918	Supplementary Figure 59	3aa ins	286–324
Non-ribosomal peptide synthetasea	WP_083036306	Supplementary Figure 60	1aa del	497–532	“Terrae” Clade
Nucleoside hydrolasea	WP_085126548	Supplementary Figure 61	2aa del	134–174
TetR/AcrR family transcriptional regulatora	WP_083037632	Supplementary Figure 62	1aa del	165–203
Carbon starvation protein Aa	WP_083035732	Supplementary Figure 63	4aa ins	593–639
Error-prone DNA polymerasea	WP_046686430	Supplementary Figure 64	5aa ins	98–124
TetR/AcrR family transcriptional regulatora	WP_083040593	Supplementary Figure 65	1aa ins	153–192
TetR family transcriptional regulatora	WP_085129961	Supplementary Figure 66	1aa ins	157–199
Hypothetical proteina	WP_083037591	Supplementary Figure 67	1aa del	47–92
Amidohydrolasea	WP_083037811	Supplementary Figure 68	1aa del	4–32
Carboxymuconolactone decarboxylase family proteina	WP_083037652	Supplementary Figure 69	1aa ins	1–29
Polyketide cyclasea	WP_085128055	Supplementary Figure 70	3aa ins	107–152
Spirocyclase AveC family proteina	WP_085128375	Supplementary Figure 71	1aa del	113–242
Hypothetical proteina	WP_083036336	Supplementary Figure 72	3aa del	362–404
TobH proteina	WP_083035918	Supplementary Figure 73	3aa ins	37–83
UDP-N-acetylmuramate–L-alanine ligase	WP_083038184	Figure 9B Supplementary Figure 74	4aa ins	131–177
DUF2236 domain-containing protein	WP_085129074	Supplementary Figure 75	1aa ins	145–190
Cobaltochelatase subunit CobN	WP_083037938	Supplementary Figure 76	2aa ins	209–255
Alpha/beta hydrolase	WP_083040154	Supplementary Figure 77	1aa ins	232–276
Potassium transporter Kef	WP_083035846	Supplementary Figure 78	1aa ins	141–180
Bifunctional tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase I	WP_083040227	Supplementary Figure 79	1aa del	330–357
Membrane protein	KKB98129	Supplementary Figure 80	1aa del	104–137
DUF222 domain-containing protein	WP_083036231	Supplementary Figure 81	5aa ins	57–100
MFS transporter	WP_083036343	Supplementary Figure 82	2aa del	232–267
Adenylate/guanylate cyclase domain-containing protein	WP_083036337	Supplementary Figure 83	1aa ins	369–407
DUF2029 domain-containing protein	WP_083037148	Supplementary Figure 84	3aa ins	154–187
Hypothetical protein	WP_052618664	Supplementary Figure 35	1aa del	199–235

^aHomologues of M. triviale and M. koreense were absent in BLASTp searches.