Table 2.
Baseline and post-drug load characteristics (post-load = following L-NMMA or Saline+PE)
| Control baseline | Control post-load | VVS baseline | VVS post-load | |
|---|---|---|---|---|
| Systolic BP (mm Hg) | ||||
| LNMMA | 119±2 | 126±3* | 122±3 | 128±5 |
| Saline+PE | 117±2 | 126±3* | 120±2 | 127±4 |
| Diastolic BP (mm Hg) | ||||
| LNMMA | 63±2 | 73±4 | 63±4 | 77±3 |
| Saline+PE | 64±2 | 76±3 | 63±4 | 77±3 |
| MAP (mm Hg) | ||||
| LNMMA | 80±1 | 91±4* | 80±2 | 93±1* |
| Saline+PE | 83±2 | 93±3* | 82±1 | 94±2* |
| HR (beats/min) | ||||
| LNMMA | 63±2 | 56±4* | 62±4 | 58±5* |
| Saline+PE | 63±2 | 57±4* | 62±4 | 59±5* |
| CO (L/min) | ||||
| LNMMA | 4.9±0.4 | 5.1±0.3 | 4.9±0.4 | 4.8±0.4 |
| Saline+PE | 5.2±0.4 | 4.9±0.3 | 4.8±0.4 | 4.6±0.5 |
| TPR (mm Hg/L/min) | ||||
| LNMMA | 16.3±1.4 | 18.7±1.0* | 16.1±1.0 | 18.6±0.9* |
| Saline+PE | 16.0±1.0 | 19.0±1.1* | 15.5±1.2 | 21.1±1.0* |
| Splanchnic BF (L/min) | ||||
| LNMMA | 1.5±0.2 | 1.2±0.1* | 1.3±0.1 | 1.0±0.1* |
| Saline+PE | 1.2±0.2 | 1.2±0.2 | 1.2±0.1 | 1.2±0.1 |
| Forearm BF (mL%/min) | ||||
| LNMMA | 2.3±0.26 | 1.98±0.33 | 2.21±0.19 | 1.91±0.34 |
| Saline+PE | 2.11±0.30 | 2.01±0.27 | 2.22±0.25 | 2.18±0.12 |
*
p<0.05 compared with baseline.
BF, blood flow; BP, blood pressure; CO, cardiac output; HR, heart rate; LNMMA, NG-monomethyl-L-arginine; MAP, mean arterial pressure; PE, phenylephrine; TPR, total peripheral resistance.