Figure 3.

ATP modulates recovery from inactivation of isolated T-currents. A, T-current traces from a representative CeM neuron generated using a paired-pulse protocol (top). Original traces show recovery from inactivation conditions with ATP at –120 mV, which lasted from 200 to 1000 ms (bottom); orange trace, 200 ms; gray trace, 400 ms; violet trace, 600 ms; blue trace, 800 ms; and green trace, 1000 ms. B, Recovery time courses with an ATP internal solution (orange) and an ATP-free internal solution (gray) fitted with a double exponential function at –120 mV with respective time constants tau (τ). Gray box indicates significantly different data points in two recording conditions. C, Recovery time courses with an ATP internal solution (orange) and ATP-free solution (gray) fitted with a double exponential function at –90 mV with respective time constants (τ). Note that recovery from inactivation was slower with the ATP-free internal solution solution at –120 mV than at –90 mV.