Table 2.
Regions of statistically significant reduced GMV in IE, SE and epileptic Beagles compared to healthy control Beagles
| Major brain region | Region of reduced GMV | Voxel per cluster | Z score | PFWE-corr | Group |
|---|---|---|---|---|---|
| Olfactory | left olfactory bulb | 34 | 5.54 | 0.000 | IE |
| right olfactory bulb | 4/3 | 4.95/4.7 | 0.011/0.02 | ||
| Parietal | left cingulate gyrus | 15 | 5.49 | 0.001 | |
| right cingulate gyrus | 8 | 5.29 | 0.002 | ||
| middle part cingulate gyrus | 6 | 5.22 | 0.003 | ||
| GM below left coronal sulcus | 9 | 5.38 | 0.001 | ||
| GM below right coronal sulcus | 3 | 5.00 | 0.009 | ||
| GM below right marginal sulcus | 3 | 4.78 | 0.019 | ||
| Temporal | left sylvian gyrus | 6 | 4.87 | 0.017 | |
| left hippocampus | 10 | 5.23 | 0.003 | ||
| right hippocampus | 7 | 4.91 | 0.014 | ||
| Temporal | GM below left medial ectosylvian sulcus | 3 | 5.03 | 0.008 | SE |
| Occipital | left occipital gyrus | 3 | 4.88 | 0.017 | |
| Olfactory | left olfactory bulb | 45 | 6.26 | 0.000 | Epileptic |
| right olfactory bulb | 51 | 6.19 | 0.000 | ||
| Frontal | frontal gyrus concentral | 31 | 5.90 | 0.000 | |
| right frontal gyrus | 10 | 5.70 | 0.000 | ||
| Parietal | left cingulate gyrus |
11/
11 |
5.81/ 5.47 | 0.000/ 0.001 | |
| right cingulate gyrus | 5/ 14 |
5.16/ 5.54 | 0.004/ 0.000 | ||
| central cingulate gyrus | 11 | 5.60 | 0.000 | ||
| GM below left coronal sulcus | 73 | 5.97 | 0.000 | ||
| GM below right coronal sulcus | 21 | 5.75 | 0.000 | ||
| Temporal | left putamen/claustrum | 35 | 5.69 | 0.000 | |
| right putamen/claustrum | 43 | 5.59 | 0.000 | ||
| left sylvian gyrus | 44/8 | 6.42/ 5.13 | 0.000/ 0.004 | ||
| right sylvian gyrus | 7 | 5.08 | 0.006 | ||
| GM below left ectosylvian sulcus | 53 | 6.21 | 0.000 | ||
| GM below right ectosylvian sulcus | 35 | 5.99 | 0.000 | ||
| GM below left medial suprasylvian gyrus | 3/3 | 4.81/ 4.72 | 0.012/ 0.012 | ||
| GM below right medial suprasylvian gyrus | 4 | 4.94 | 0.012 | ||
| right suprasylvian gyrus | 4 | 4.94 | 0.012 | ||
| left hippocampus | 67/13/6 | 5.76/ 5.99/ 5.32 | 0.000/ 0.000/ 0.002 | ||
| right hippocampus | 49/5/16 | 5.89/ 4.35/ 6.26 | 0.000/ 0.001/ 0.000 | ||
| GM below left marginal sulcus | 4 | 5.38 | 0.001 | ||
| GM below right marginal sulcus | 23 | 6.17 | 0.000 | ||
| Occipital | occipital gyrus | 8/17/6/144 | 5.15/ 5.39/ 5.21/ 6.28 | 0.004/ 0.001/ 0.003/0.000 | |
| GM below medial suprasylvian gyrus | 3/3 | 5.01/ 5.00 | 0.008/ 0.009 | ||
| Cerebellar | left cerebellum | 6/6/6/7 | 5.85/ 5.53/ 5.37/ 5.09 | 0.000/ 0.000/ 0.001/ 0.005 | |
| right cerebellum | 9/12/7/5 | 5.73/ 5.39/ 5.29/ 5.12 | 0.000/ 0.001/ 0.002/ 0.005 |
Underlined: significant changes in GMV even with an extend threshold of 10 voxels (GMV grey matter volume, GM grey matter, IE idiopathic epilepsy, SE structural epilepsy)