Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 20;18:207. doi: 10.1186/s12885-018-4123-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — Administration of 3-BP or 2DG caused a remarkable ATP production decrease (a) and cleaved Caspase-3 increasement (b) in HCT-8/5-Fu cells, while caused no obvious change to HCT-8 cells (a, b) (n = 4, *p < 0.05, one-way ANOVA). The elevated cleaved Caspase-3 induced by 2DG decreased dramatically with the administration of BAPTA-AM (b). (n = 4, *p < 0.05, one-way ANOVA). (c) Administration of 3-BP or 2DG caused increasement of [Ca²⁺]_i level in HCT-8/5-Fu cells, while caused no obvious change to HCT-8 cells (n = 4, *p < 0.05, one-way ANOVA). Scale bars, 20 μm. d The apoptotic cells rate in HCT-8/5-Fu cells increased dramatically after treated with 2DG. The elevated apoptotic cells rate induced by 2DG decreased dramatically with the administration of BAPTA-AM (n = 4)