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. Author manuscript; available in PMC: 2018 Jul 21.
Published in final edited form as: ACS Chem Biol. 2017 May 31;12(7):1848–1857. doi: 10.1021/acschembio.7b00175

Fig 4.

Fig 4

Assessment of inhibition for EcDHFR wild-type and rescue-variants (A) by deoxybenzoin and stilbenoid class of small-molecules. The assessment was carried out in duplicate at a single-concentration of the inhibitor around its experimental IC50-values for the wild-type enzyme. (B) Estimation of IC50-values of ononetin for wild-type, A26T/L28R mutant, P21L/L28R mutant and L28R mutants. (C) Estimation of IC50-values of resveratrol for wild-type, A26T/L28R mutant, P21L/L28R mutant and L28R mutants.