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Regulation of FASN activity and expression by HER2. In HER2-positive cancer cells, HER2 overexpression increases FASN expression through the PI3K/AKT and MEK/ERK pathways. HER2 also directly phosphorylates and enhances the enzymatic activity of FASN. FASN in turn upregulates HER2 expression, thereby establishing an autoregulatory loop. HER2; human epidermal growth factor receptor 2, FASN; fatty acid synthase, ERK; extracellular-signal-regulated kinase 2.
