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Regulation of BCL-2 family proteins. BCL-2 family proteins are divided into three groups: antiapoptotic BCL-2 family proteins (BCL-2, BCL-W, BCL-xL, MCL-1, and A1), proapoptotic multidomain proteins (BAX, BAK, and BOK), and proapoptotic BH3-only proteins (BIM, PUMA, BID, BAD, and NOXA).
