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The interaction between antiapoptotic BCL-2 family proteins and proapoptotic BCL-2 family members. BCL-2 and BCL-xL interact with all of the BH3-only proteins except for NOXA, while MCL-1 can bind to all of the BH3-only protein except for BAD. Of note, BIM, PUMA, and BID are capable of interacting with all of the antiapoptotic BCL-2 family proteins. Furthermore, BIM, PUMA, and BID can directly activate BAX and BAK in the direct activator–derepressor model.
