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Target genes of HIF-1. HIF-1 promotes glycolysis by transcriptionally upregulating GLUT1, GLUT3, HK1, and HK2. HIF-1 also suppresses oxidative phosphorylation by the upregulation of gene expression of BNIP3, BNIP3L, LDHA, and PDK1. In addition, HIF-1 can inhibit apoptosis by suppressing the expression of BID. BNIP3; BCL-2/E1B-19 kDa interacting protein 3, BNIP3L; BNIP3-like.
