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. Author manuscript; available in PMC: 2018 Feb 20.
Published in final edited form as: Int Rev Cell Mol Biol. 2016 Jul 30;327:43–87. doi: 10.1016/bs.ircmb.2016.06.006

Figure 8.

Figure 8

Anti-apoptotic function of AKT. AKT prevents apoptosis by suppressing induction of PUMA and by inhibiting GSK3-dependent degradation of MCL-1. In addition, AKT promotes translocation of GLUT to cellular membrane and activation of HK. GSK3; glycogen synthase kinase 3.