Table I.
The Gene Ontology (GO) terms significantly enriched for the upregulated genes.
| Term | Count | P-value | Gene symbol |
|---|---|---|---|
| GO:0030334 - regulation of cell migration | 25 | 2.83E-12 | DLC1, PDGFB, ENPP2, KIT, ADA, TGFB1, ACE, S1PR1, INS, TEK, ROBO4, TIE1, LAMB1, ICAM1, PTPRM, IGF2, VASH1, THY1, KDR, LAMA4, LAMA3, CLIC4, PDGFRB, ARAP3, IGFBP3, F2R |
| GO:0001568 - blood vessel development | 27 | 2.74E-10 | EMCN, CAV1, ATP5B, COL3A1, WASF2, ELK3, CDH5, GJC1, PTK2, ACE, S1PR1, CD44, ROBO4, LOX, PLXND1, EPAS1, MYO1E, MMP19, COL15A1, UBP1, THY1, KDR, LAMA4, BGN, PLXDC1, NOTCH4, ENG |
| GO:0001944 - vasculature development | 27 | 4.67E-10 | EMCN, CAV1, ATP5B, COL3A1, WASF2, ELK3, CDH5, GJC1, PTK2, ACE, S1PR1, CD44, ROBO4, LOX, PLXND1, EPAS1, MYO1E, MMP19, COL15A1, UBP1, THY1, KDR, LAMA4, BGN, PLXDC1, NOTCH4, ENG |
| GO:0048514 - blood vessel morphogenesis | 22 | 4.70E-08 | CAV1, EMCN, EPAS1, ATP5B, MYO1E, MMP19, WASF2, COL15A1, ELK3, UBP1, GJC1, THY1, KDR, PTK2, ACE, S1PR1, BGN, PLXDC1, NOTCH4, ROBO4, PLXND1, ENG |
| GO:0016477 - cell migration | 24 | 2.82E-07 | ICAM1, PDGFB, ATP5B, PODXL, WASF2, ITGA1, KIT, TGFB1, KDR, VCAM1, NCK2, EDNRB, PTK2, ITGA6, CD44, CD34, ITGA5, FYN, PDGFRB, MSN, LAMC1, ENG, MYH10, THBS4 |
| GO:0007167 - enzyme linked receptor protein signaling pathway | 24 | 1.11E-05 | PDGFB, EFNA1, ADCYAP1R1, COL3A1, FKBP1A, KIT, EPHB3, EPHB4, TGFB1, PTK2, INS, TEK, TIE1, PTPRE, SOCS2, MYO1E, IGF2, KDR, LEFTY1, NCK2, PRLR, PDGFRB, TGFB1I1, ENG, GFRA2 |
| GO:0009966 - regulation of signal transduction | 42 | 4.27E-05 | DLC1, FGD2, CAV1, PDGFB, TBC1D9, EFNA1, AGFG2, PREX2, ASAP2, ASAP1, ITPKB, FKBP1A, KIT, CD74, MCF2L, TGFB1, ADA, S1PR1, NOD1, INS, RAPGEF5, RHOC, TRAF5, RAMP2, SOCS2, PSD3, ITGA1, IGF2, ARHGEF15, CD40, THY1, NCK2, TNFSF10, ARRB1, RGS5, TGFB1I1, GRK5, IGFBP2, ARAP3, ENG, IGFBP3, MAP3K11, F2R |
| GO:0009888 - tissue development | 31 | 8.58E-04 | DLC1, CAV1, COL3A1, FKBP1A, TIMP3, TGFB1, GJC1, EDNRB, S1PR1, CD44, SERPINE1, TIE1, F11R, BMP1, HSPG2, MECOM, SNAI2, COL5A2, FZD6, KDR, NOTCH3, LAMA3, SPRR1B, NOTCH4, PDGFRB, LAMC1, TGFB1I1, ENG, FABP5, F2R, MYH10 |
| GO:0008284 - positive regulation of cell proliferation | 22 | 1.26E-03 | GNAI2, PDGFB, BTC, CDK6, IGF2, KIT, CD40, PNP, ADA, TGFB1, KDR, VCAM1, NCK2, S1PR1, INS, NOTCH4, AVPR1A, PDGFRB, LAMC1, LAMB1, TRAF5, THPO, F2R |
| GO:0043067 - regulation of programmed cell death | 34 | 2.71E-03 | DLC1, FGD2, BID, CADM1, BTC, KIT, TIMP3, ADA, TGFB1, MCF2L, CD74, EDNRB, PEA15, PCGF2, NOD1, CASP4, CD44, INS, TRAF5, PHLDA1, HIP1, GIMAP5, ACTN4, SOCS2, ITGA1, IGF2, NLRP1, CASP10, TNFSF10, PRLR, ETS1, IGFBP3, FAIM2, F2R, MAP3K11 |
| GO:0007166 - cell surface receptor linked signal transduction | 64 | 3.44E-03 | PDGFB, EFNA1, PREX2, WASF2, LPAR4, ITPKB, TGFB1, LPHN2, EDNRB, S1PR1, ELTD1, TIE1, RAMP2, GPR176, SOCS2, CD40, OR10J1, THY1, LEFTY1, NCK2, CPE, CHRM2, LPAR6, GPR56, PDGFRB, TGFB1I1, GNAI2, GNAI1, ENPP2, ADCYAP1R1, COL3A1, GNG11, FKBP1A, GAST, KIT, EPHB3, EPHB4, APLNR, PTK2, DOCK1, INS, TEK, PTPRE, MYO1E, ITGA1, IGF2, OR51E2, CENPI, KDR, FZD6, NOTCH3, SEMA6A, LAMA3, PRLR, ITGA6, FYN, ITGA5, HEYL, NOTCH4, AVPR1A, GRK5, ENG, GFRA2, GPR116, F2R |
| GO:0042981 - regulation of apoptosis | 33 | 4.22E-03 | DLC1, FGD2, BID, CADM1, BTC, TIMP3, ADA, TGFB1, MCF2L, CD74, EDNRB, PEA15, PCGF2, NOD1, CASP4, CD44, INS, TRAF5, PHLDA1, HIP1, GIMAP5, ACTN4, SOCS2, ITGA1, IGF2, NLRP1, CASP10, TNFSF10, PRLR, ETS1, IGFBP3, FAIM2, F2R, MAP3K11 |
| hsa04514: Cell adhesion molecules (CAMs) | 22 | 2.32E-09 | F11R, ICAM1, PTPRM, CADM1, ICAM2, CLDN5, HLA-A, HLA-C, CD40, HLA-B, HLA-E, HLA-DMA, HLA-DQA1, HLA-G, CDH5, VCAM1, ITGA6, CD34, PECAM1, HLA-DPA1, HLA-DPB1, JAM2, HLA-DRA |
| hsa04512: ECM-receptor interaction | 17 | 1.49E-08 | COL4A2, COL4A1, COL3A1, ITGA1, HSPG2, COL5A2, VWF, LAMA4, LAMA3, CD44, ITGA6, ITGA5, COL6A3, SV2B, LAMC1, LAMB1, THBS4 |
| hsa05200: Pathways in cancer | 19 | 3.04E-02 | BID, COL4A2, COL4A1, PDGFB, EPAS1, CDK6, KIT, MECOM, TGFB1, FZD6, PTK2, LAMA4, LAMA3, ITGA6, ETS1, PDGFRB, LAMC1, LAMB1, TRAF5 |