Table I.
miRNAs with statistical differences in expression between the pain and control groups.
| miRNA | P-value | FDR | Fold-change | Regulation trend | Sequence length, nt | Sequence (5′-3′) |
|---|---|---|---|---|---|---|
| DHSC group | ||||||
| miR-3573-5p | 0.0068 | 1.000 | 0.70 | Down | 22 | UGAGGGGCAGUGAUAGAAAGGA |
| miR-3074 | 0.041413 | 1.000 | 0.90 | Down | 22 | GAUAUCAGCUCAGUAGGCACCG |
| miR-1193-3p | 0.025148 | 1.000 | 1.23 | Up | 22 | UAGGUCACCCGUUUUACUAUCC |
| miR-410-5p | 0.040567 | 1.000 | 1.23 | Up | 21 | AGGUUGUCUGUGAUGAGUUCG |
| miR-340-5p | 0.018692 | 1.000 | 1.48 | Up | 22 | UUAUAAAGCAAUGAGACUGAUU |
| AC group | ||||||
| miR-208a-3p | 0.018404 | 0.997 | 0.37 | Down | 18 | AUAAGACGAGCAAAAAGC |
| miR-6216 | 0.028229 | 0.997 | 0.71 | Down | 23 | GAUACACAGAGGCAGGAGGAGAA |
| miR-3580-3p | 0.034532 | 0.997 | 0.72 | Down | 22 | UGACUAGGGUAGUAUGAGUAGA |
| miR-205 | 0.045209 | 0.997 | 1.41 | Up | 23 | UCCUUCAUUCCACCGGAGUCUGU |
| miR-25-5p | 0.030307 | 0.997 | 1.46 | Up | 22 | AGGCGGAGACACGGGCAAUUGC |
| miR-702-3p | 0.035705 | 0.997 | 1.49 | Up | 23 | UGCCCACCCUUUACCCCACUCCA |
| miR-501-3p | 0.024475 | 0.997 | 1.65 | Up | 23 | AAUGCACCCGGGCAAGGAUUUGG |
| let-7f-5p | 0.035378 | 0.997 | 1.70 | Up | 22 | UGAGGUAGUAGAUUGUAUAGUU |
| miR-381-5p | 0.032536 | 0.997 | 1.80 | Up | 22 | AGCGAGGUUGCCCUUUGUAUAU |
| miR-30c-1-3p | 0.011214 | 0.997 | 1.87 | Up | 22 | CUGGGAGAGGGUUGUUUACUCC |
| miR-671 | 0.028852 | 0.997 | 1.87 | Up | 21 | UCCGGUUCUCAGGGCUCCACC |
| miR-184 | 0.006879 | 0.997 | 2.42 | Up | 22 | UGGACGGAGAACUGAUAAGGGU |
| T group | ||||||
| miR-34b-5p | 0.04851 | 0.971 | 0.62 | Down | 23 | AGGCAGUGUAAUUAGCUGAUUGU |
| miR-181d-3p | 0.0342 | 0.971 | 0.65 | Down | 20 | CCACCGGGGGAUGAAUGUCA |
| miR-484 | 0.027441 | 0.971 | 0.66 | Down | 22 | UCAGGCUCAGUCCCCUCCCGAU |
| miR-370-5p | 0.016922 | 0.971 | 0.70 | Down | 24 | CAGGUCACGUCUCUGCAGUUACAC |
| miR-9b-5p | 0.008269 | 0.971 | 0.78 | Down | 19 | UUCGGUUAUCUAGCUUUAU |
| miR-1912-3p | 0.017277 | 0.971 | 0.79 | Down | 19 | CACAGAACAUGCAGUGAGA |
| miR-759 | 0.018461 | 0.971 | 0.81 | Down | 22 | GCAGAGUGCAAACAAUUUUGAC |
| miR-463-5p | 0.036635 | 0.971 | 0.81 | Down | 21 | UACCUAAUUUGUUGUCCAUCA |
| miR-193-3p | 0.045474 | 0.971 | 0.81 | Down | 22 | AACUGGCCUACAAAGUCCCAGU |
| miR-802-5p | 0.040079 | 0.971 | 0.83 | Down | 21 | UCAGUAACAAAGAUUCAUCCU |
| miR-218a-5p | 0.019683 | 0.971 | 0.84 | Down | 21 | UUGUGCUUGAUCUAACCAUGU |
| miR-31b | 0.031174 | 0.971 | 0.84 | Down | 19 | CUAUGCCAGCAUCUUGCCU |
| miR-3593-5p | 0.033797 | 0.971 | 0.87 | Down | 22 | UGGCCUCCGCAGGGUUGAAGCU |
| miR-3570 | 0.039038 | 0.971 | 1.15 | Up | 22 | GGUACAAUCAACGGUCGAUGGU |
| miR-3588 | 0.018922 | 0.971 | 1.19 | Up | 22 | UCACAAGUUAGGGUCUCAGGGA |
| miR-664-3p | 0.039461 | 0.971 | 1.30 | Up | 22 | UAUUCAUUUACUCCCCAGCCUA |
| miR-488-3p | 0.025485 | 0.971 | 1.41 | Up | 21 | UUGAAAGGCUGUUUCUUGGUC |
| miR-30c-1-3p | 0.009129 | 0.971 | 2.03 | Up | 22 | CUGGGAGAGGGUUGUUUACUCC |
| miR-106b-3p | 0.018801 | 0.971 | 2.08 | Up | 22 | CCGCACUGUGGGUACUUGCUGC |
| miR-93-3p | 0.012217 | 0.971 | 2.69 | Up | 23 | ACUGCUGAGCUAGCACUUCCCGA |
| miR-28-5p | 0.041407 | 0.971 | 2.85 | Up | 22 | AAGGAGCUCACAGUCUAUUGAG |
| miR-873-5p | 0.02098 | 0.971 | 2.93 | Up | 21 | GCAGGAACUUGUGAGUCUCCU |
| B group | ||||||
| miR-455-3p | 0.028562 | 0.997 | 0.32 | Down | 22 | GCAGUCCACGGGCAUAUACACU |
| miR-32-3p | 0.030898 | 0.997 | 0.47 | Down | 22 | GCAAUUUAGUGUGUGUGAUAUU |
| miR-466b-2-3p | 0.032782 | 0.997 | 0.57 | Down | 21 | AUAUACAUACACACAUACACA |
| miR-702-3p | 0.035054 | 0.997 | 0.62 | Down | 23 | UGCCCACCCUUUACCCCACUCCA |
| miR-742-5p | 0.035279 | 0.997 | 0.72 | Down | 21 | UACUCACAUGGUUGCUAAUCA |
| miR-195-3p | 0.021132 | 0.997 | 0.73 | Down | 23 | CCAAUAUUGGCUGUGCUGCUCCA |
| miR-509-3p | 0.045567 | 0.997 | 0.77 | Down | 22 | UGAUUGACAUGUCUGCAGUGGA |
miRNA/miR, microRNA; FDR, false discovery rate; DHSC, dorsal horn of the spinal cord; AC, anterior cingulate; T, thalamus; B, blood.