Table III.

Significantly up- and downregulated miRNAs between 3- and 12-month-old spontaneously hypertensive rats (including those expressed from the 5′-arm and 3′-arm).

miRNA	Normalized read no.		Fold (log2)	P-value
	3 m	12 m
Upregulated
rno-miR-132-3p	7.31	16.31	1.16	<0.001
rno-miR-132-5p	2.07	6.37	1.62	0.03
rno-miR-182	6.43	15.16	1.24	0.01
rno-miR-208b-3p	64.66	250.22	1.95	<0.001
rno-miR-212-3p	0.95	4.03	2.08	0.04
rno-miR-214-3p	68.72	153.49	1.16	<0.001
rno-miR-218a-5p	69.29	140.69	1.02	<0.001
rno-miR-221-3p	116.83	290.16	1.31	<0.001
rno-miR-221-5p	5.99	12.20	1.03	0.03
rno-miR-222-3p	43.55	109.15	1.33	<0.001
rno-miR-375-3p	0.92	33.60	5.19	<0.001
rno-miR-129-5p	1.18	5.56	2.24	0.01
rno-miR-9a-3p	2.65	8.30	1.65	0.04
rno-miR-31a-5p	4.30	19.85	2.21	<0.001
rno-miR-183-5p	3.01	7.91	1.39	0.02
rno-miR-224-5p	70.84	152.60	1.11	<0.001
rno-miR-31b	0.90	5.81	2.70	<0.001
rno-miR-147	3.23	8.40	1.38	0.03
rno-miR-708-5p	3.86	8.89	1.20	0.04
rno-miR-92b-3p	1.34	4.73	1.82	0.05
rno-miR-511-3p	2.30	6.63	1.53	0.03
Downregulated
rno-miR-208a-5p	20.33	9.16	−1.15	<0.001
rno-miR-208a-3p	521.89	187.50	−1.48	<0.001
rno-miR-181c-3p	12.05	5.79	−1.06	0.01
rno-miR-547-3p	9.81	4.5236	−1.12	0.02
rno-miR-208b-5p	9.38	4.1846	−1.17	0.03

m, month; miR, microRNA.