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. 2017 Dec 22;41(3):1224–1232. doi: 10.3892/ijmm.2017.3347

Figure 5.

Figure 5

DRA silencing and overexpression modulated TNF-α expression levels in Caco2BBE cells. (A) Knockdown of DRA increased TNF-α mRNA expression levels in Caco2BBE cells. (B) The level of DRA protein expression was markedly decreased following transfection with siDRA. (C) DRA silencing correspondingly increased TNF-α expression levels in the supernatant of Caco2BBE cells. (D) The TNF-α mRNA expression level was significantly decreased in DRA overexpression Caco2BBE cells. *P<0.05. DRA, downregulated-in-adenoma; TNF-α, tumor necrosis factor-α; NC, normal control.