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. 2017 Dec 20;41(3):1339–1348. doi: 10.3892/ijmm.2017.3334

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Copyright: © Jin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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NO donor treatment attenuates ERK1/2 phosphorylation in U251 glioma cells. (A and B) Alterations in p-ERK1/2 expression at the indicated time-points following SNP (2 mM) or GSNO (500 µM) treatment were detected by western blotting and were semi-quantified. (C and D) Alterations in p-ERK1/2 expression following treatment with the indicated concentrations of SNP or GSNO were examined by western blotting and were semi-quantified. p-ERK1/2 expression was normalized to total ERK1/2. ^*P<0.05 and ^**P<0.01 compared with the control group (0). ERK1/2, extracellular signal-regulated kinase 1/2 GSNO, S-nitrosoglutathione; NO, nitric oxide; p-ERK1/2, phosphorylated-ERK1/2; SNP, sodium nitroprusside.