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. 2018 Feb 1;7:e31895. doi: 10.7554/eLife.31895

Figure 5. Time frequency representations and dopamine-dependent-scaling of gamma activity in the subgroup of seven patients ON and OFF medication.

Figure 5.

Significant movement-related modulation of the contralateral baseline corrected time-frequency representation was found for theta, beta and gamma frequency bands (ON: A- right panel, OFF: D – right panel; p<0.05, FDR corrected) in the dopaminergic ON (A) and OFF (B) state in a subgroup of seven patients. Scaling of movement to gamma oscillations was present only in the dopaminergic ON, but not in the OFF state (C). Gamma band activity difference between ON and OFF states were scaled to movement velocity (D) and significantly different only in the medium and large movement conditions in the subgroup of seven patients with OFF recordings. No significant difference was found for the theta and beta bands (not shown). An increasing difference in gamma power between ON and OFF state toward the large movement condition is shown in (E). Across conditions, grand average gamma activity was significantly higher in the dopaminergic ON state, when compared to the OFF state (C; p<0.001).