Video 2. Overview of the cryo-EM density and detailed view of the bound CDP substrate, dATP specificity effector, and loop 2 conformation.

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DOI: 10.7554/eLife.31502.015

Starting from a view down the three-fold symmetry axis, the structure rotates while zooming through the center of the ring for a view of the loop 2 region that confers substrate preference as seen in Figure 5A, and then rocks back and forth over a range of 30°. Density is shown as mesh colored according to regions of the structural model as in Figure 1.